Leah Guthrie is an Assistant Professor in the Department of Bioengineering at UC Berkeley.
What microbiome-related work do you do?
Human gut microbiotas are malleable generators of chemically diverse signaling molecules that mediate intra- and inter-species and inter-kingdom-level communication and signaling. Remarkably, bacterial processing of ingested food and drug compounds alone accounts for thousands of metabolites. Â many of which are poorly studied despite possessing disease connections. Our research aims to decipher how diet-derived microbiome-dependent metabolites (MDMs) modulate the biology of kidney cells and define the biochemical and ecological mechanisms mediating systemic and tissue-specific heterogeneity in MDM levels. We use mass spectrometry, chemoinformatics, and molecular biology approaches to address questions related to the production and function of MDMs.
For those interested in your work, could you suggest one key reading from your recent papers?
Multiomic microbiome analysis: Guthrie et al. 2023
Learn more about Leah at the Guthrie Lab Website!